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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often described as focusing on practical aspects of design which include the recruitment process and consent, adhering and the use routinely available equipment.

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A practical trial that employs various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for practical trials to be valid and helps to reduce the chance of bias in the results. Too much heterogeneity, however, can cause problems with the design of the trial.

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Pragmatic Play is known for its top-notch games, and for providing a superior user experience. Its software is designed to work with mobile devices and supports different languages. Despite its infancy, it has already established itself as a premier gaming platform for casinos. The most recent releases include Wolves 5 reel video slot with a healthy RTP and stunning graphics. Its other notable titles are Wolf Gold and Chilli Heat.

Pragmatic trials are designed to replicate real-world situations and have the highest external validity. They are usually requested by policy makers and practitioners to inform their decision making. They can also be a great method of determining the causal relationship between the intervention and its effects. However, they should not be used to substitute for explanatory trials.

The pragmatism concept is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis as well as pragmatic trials that inform policy and 프라그마틱 practice decisions. They also proposed an approach to pragmatic trials, which they called PRECIS.2 This tool sought to define the characteristics of a pragmatic study, including the recruitment process, the design and implementation of the intervention, as well as the follow-up.

There is a growing increase in the number of pragmatic trials that have been published. A recent Medline search using the terms naturalistic and pragmatic, limited to randomized controlled trials (RCTs) resulted in 34 articles, shown in red in Figure 2. This is an indication that the health sciences community is becoming more sensitive to the subject of pragmatic thinking. However, it is important to remember that the majority of these studies were conducted in primary care settings.